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Seminar: 2019 Best Dissertation Award Seminars

Sualyneth Galarza & Ashish Kumar

Date/Time: 

Thursday, April 8, 2021 - 11:30am

Location: 

(will be held via Zoom, contact wallace@ecs.umass.edu for a link)

Details: 

 

Sualyneth Galarza, Ph.D.

Shelly Peyton Research Group
 

Microenvironments Matter:

Tailoring Cell Culture Platforms from the Bench through Manufacturing”

Thursday, April 8, 2021, 11:30 a.m.

Zoom Virtual Seminar, UMass Amherst

(Email wallace@ecs.umass.edu for Zoom Link)

Abstract

The behavior of cells is determined not only by their identity but also by cues provided by their microenvironment. Within tissues, cells are surrounded by the extracellular matrix (ECM) which is a non-cellular component that provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation and homeostasis. The complexity of this microenvironment is dynamic and cues like stiffness and shear effect change depending on the state of health of the local system. Taken together these can act like a feedback loop triggering and responding to cell behavior. Hence, it is critical to optimize cell culture environments to reproduce cell physiological phenotypes in vitro, but also to guide their responses in the production of proteins, growth factors and other biologics during development and manufacturing. With that aim, this talk will cover the process of tailoring the cell microenvironment to recreate physiological responses of astrocytes in an in vitro culture and during clinical manufacturing of mammalian cells to ensure we can deliver biologics with high efficacy and quality.

 

Bio

Sualyneth Galarza is a Business Analyst within the Life Science CEO office team. Since joining MilliporeSigma in June 2019, Sualyneth has supported technology and product development projects for Mobius®, PowerMIX®, CelliconTM and other products within the Single-Use & Integrated Systems R&D as an Applications Engineer for BioProcessing. Prior to joining Millipore, Sualyneth performed as MS&T engineer at Eli Lilly supporting GMP manufacturing for Cialis® and Strattera® and optimization of mixing and granulation steps. Sualyneth earned a B.S. in Chemical Engineering from the University of Puerto Rico, Mayaguez, a Certification in Pharmaceutical Manufacturing, and a Ph.D. degree in Chemical Engineering at the University of Massachusetts Amherst focused on biomaterials tailored to recreate tissue environments optimized for cell culture applications.

 

 

 

Ashish Kumar, Ph.D.

Dimitrios Maroudas Research Group

 

Recent Advances in Lithographic Techniques that Enable Fabrication of Small Semiconductor Feature Sizes”

Thursday, April 8, 2021, 12:00 p.m.

Zoom Virtual Seminar, UMass Amherst

(Email wallace@ecs.umass.edu for Zoom Link)

Abstract

Making semiconductor feature sizes as small as possible has many benefits, for example, devices with smaller feature sizes have faster performance and lower overall power consumption. Almost all electronic components get fabricated layer by layer on a silicon wafer through chemical processes that use lithography as a step to transfer patterns of each layer onto the silicon wafer. Lithography is the limiting step that controls the size of the semiconductor features. In this presentation, we will discuss recent advances in lithographic techniques that have enabled the ever-shrinking of semiconductor feature sizes. More specifically, we will discuss the adoption of projection lithography and the simplification of circuit layouts to facilitate lithography through grating masks. Furthermore, we will discuss the implementation of resolution enhancement techniques such as immersion lithography, optical proximity correction, off-axis illumination, phase shift masks, pitch division, etc. that have enabled fabrication of feature sizes beyond the capabilities of traditional lithographic tools.

 
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