The University of Massachusetts Amherst
University of Massachusetts Amherst

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Seminar: Hakho Lee, Harvard/Mass. General Hospital, Title: "Promise of liquid biopsy for cancer management"


Tuesday, October 5, 2021 - 11:30am


LGRT 201




The premise of precision medicine in cancer demands better molecular biomarkers and bioanalytical technologies to diagnose malignancy ideally at its early stages, monitor tumor progression and metastasis, stratify patients to the most suitable treatment, predict treatment response and resistance, and detect recurrence. Tumors shed various biological components into circulation – detecting these targets (liquid biopsy) is rapidly emerging as a new venue for biomarker development and clinical applications. This presentation will specifically focus on extracellular vesicles (EVs), nanoscale particles (50 – 200 nm in diameter) that carry molecular constituents of their originating cells. Two major topics will be discussed: i) platform developments for EV detection and ii) pilot clinical investigations that evaluated EVs clinical utility.


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