The University of Massachusetts Amherst
University of Massachusetts Amherst

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Seminar: Hyunmin Yi, Tufts University, “Nanobiofabrication: Integrated Fabrication Approaches for Biopolymeric-Synthetic Hybrid Materials”


Tuesday, September 27, 2022 - 11:30am


LGRT 201 & via Zoom (email for a link)


Host:  Jungwoo Lee


Our overall research interests are in understanding and exploiting selective and programmable properties of biological materials and interactions for the controlled fabrication of advanced functional materials at micro and nano scales (i.e., nanobiofabrication) such as multifunctional biosensors, biophotonic devices, and precious metal nanocatalysts under mild conditions, for biomedical, environmental, and biotechnology applications. Three representative examples will be presented in this talk to highlight the advantages of biological materials we have exploited. First, synthesis of small and uniform metal nanocatalysts with pristine and active surfaces under mild aqueous conditions remain challenging despite their importance in sustainable chemistry. We have utilized genetically modified tobacco mosaic virus (TMV) as a biological nanotemplate for controlled synthesis of small palladium nanoparticles with high catalytic activity and stability in liquid phase reactions. Second, hydrogel microparticles with controlled network structures and geometries have gained increasing attention in various applications as biosensing platforms for medical diagnostics, biological threat detection and bioprocess monitoring.  However, it still remains challenging to manufacture such microparticles with macroporous structures and multifunctionality and in a simple, cost-efficient and reliable manner.  We exploit a simple micromolding-based approach in order to fabricate highly uniform poly(ethylene glycol) (PEG)- and poly(acrylamide) (PAAm)-based hydrogel microspheres and shape-encoded microparticles, in which a potent aminopolysaccharide chitosan providing chemically reactive and abundant amine groups is incorporated offering facile conjugation handles for enhanced protein conjugation capacity and kinetics and allowing programmable protein conjugation.  Finally, our recent progress on stimuli-responsive synthetic and biopolymeric films containing micropatterned artificial opal structures as well as opal microparticles will also be presented to demonstrate the utility of biological materials interactions.

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