The University of Massachusetts Amherst
University of Massachusetts Amherst

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Seminar: Manu Platt, Georgia Tech, "Quantitative Dissection of Proteolytic Networks Governing Tissue Remodeling in Health and Disease"


Thursday, April 20, 2017 - 10:00am


S330 LSL


CBI Student Invited Speaker, Host: Alyssa Schwartz

Patient-to-patient variability in disease progression continues to complicate clinical decisions in diagnosis and treatment. We focus on individual variability in production of cysteine cathepsins, powerful proteases that are the most potent mammalian collagenases and elastases and are upregulated during tissue-destructive disease progression. During this seminar, Dr. Platt will discuss 1) experimental and computational tools he has developed to better quantify and model the proteolytic network’s role in disease progression, 2) fundamental insights and consequences of proteolytic network perturbation on extracellular matrix remodeling, and 3) applications for personalized medicine strategies to address patient variability in breast cancer invasion and progression and also in cardiovascular remodeling contexts.

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