Jungwoo Lee

Associate Professor

BME Adjunct

Departmental Honors Coordinator

Pronouns: he/his

Department of Chemical Engineering
University of Massachusetts Amherst
N567 Life Sciences Laboratories
240 Thatcher Rd
Amherst MA 01003-9364

Lee Research Group

jungwoo@engin.umass.edu

413.545.6290 (office)

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Education

Post-doc, Massachusetts General Hospital, Harvard Medical School
Ph.D Biomedical Engineering, University of Michigan 2009
M.S. Biomedical Engineering, University of Michigan 2005
B.E. Chemical Engineering, Korea University 2003

Research

Translational Biomaterials
Bone Marrow Tissue Engineering
Microenvironment Aging and Cancer
Biomedical Imaging

The overall goal of my research group is to deliver enabling and translational platform technologies that can advance basic biomedical research, solve various medical problems, and ultimately improve patient care. We design and manufacture a broad range of materials to construct standardized, functional human tissue models, and apply multi-dimensional imaging techniques to quantitatively capture complex, dynamic biological processes. Current research activities focus on bone marrow that implicates clinical significance as a major reservoir of adult stem cells, a key regulator of body homeostasis, and, in case of cancerous lesion, a potent instigator of metastatic spread. Our fundamental question is underlying roles of ECM composition, structure, and physical forces in forming and sustaining highly regenerative bone marrow niches and their transformation under pathological and aging processes. For basic and translational research, we are developing manipulatable organotypic bone marrow tissue constructs that can deliver new insights into bone marrow biology and clinical strategies for therapeutic targeting bone marrow niche.

Publications

https://scholar.google.com/citations?user=B5XJRfAAAAAJ

Jungwoo Lee, Jennifer B. Wang, Francesca Bersani, Biju Parekkadan “Capture and Printing of Fixed Stromal Cell Membrane for Bioactive Display on PDMS Surfaces” Langmuir (2013) 29(34) 10611-10616.
O. Berk Usta, Yeonhee Kim, Sinan Ozer, Bote G. Bruinsma, Jungwoo Lee, Esin Demir, Tim A. Berendsen, Cathelyne F. Puts, Maria-Louisa Izamis, Korkut Uygun, Basak E. Uygun, Martin L. Yarmush “Supercooling as a viable non-freezing cell preservation method of rat hepatocytes” Plus One (2013) 8(7) e69334.
Jack M. Milwid, Matthew Li, Joy Jiao, Jungwoo Lee, Martin L. Yarmush, and Biju Parekkadan “Evidence of a Hematopoietic Origin of Human Bone Marrow Stromal Cells” Journal of Bone Marrow Research (2013) 1:113.
John Milwid, Takaharu Ichimura, Matthew Li, Yunxin Jiao, Jungwoo Lee, Joshua Yarmush, Biju Parekkadan, Arno Tilles, Joseph V. Bonventre and M. L. Yarmush “Secreted Factors From Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury” Stem Cells International (2012), Article ID 392050, 12 pages 2012. Doi:10.1155/2012/392050.
Jungwoo Lee, Matthew Li, Jack Milwid, Joshua Dunham, Claudio Vinegoni, Rostic Gorbatov, Yoshiko Iwamoto, Fangjing Wang, Keyue Shen, Kimberley Hatfield, Marianne Enger, Sahba Shafiee, Emmet McCormack, Benjamin Ebert, Ralph Weissleder, Martin Yarmush, Biju Parekkadan “Implantable Microenvironments to Attract Hematopoietic Stem/Cancer Cells” Proceedings of the National Academic Sciences (2012) 109(48) 19638-19643.
Tim A. Berendsen, Bote G. Bruinsma, Jungwoo Lee, Vincent D’Andrea, Qiang Lui, Maria-Louisa Izamis, Korkut Uygun, Martin L. Yarmush “A simplified sub-normothermic machine perfusion model restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation” Transplantation Research (2012) 1:6 doi:10.1186/2047-1440-1-6.
Matthew Li, Arno Tilles, Jack M. Milwid, Mohamed Hammad, Jungwoo Lee, Martin L. Yarmush, Biju Parekkadan “Phenotypic and Functional Characterization of Human Mesenchymal Stromal Cells in Hollow Fiber Bioreactors” Journal of Tissue Engineering and Regenerative Medicine (2012) 6(5) 369-377.
Soo-Hwan Jeong, Jungwoo Lee, Dengteng Ge, Kai Sun, Takuya Nakashima, Seong Il Yoo, Ashish Agarwal, Yao Li, Nicholas A. Kotov “Reversible Nanoparticle Gels with Colour Switching” Journal of Materials Chemistry (2011) 31(21), 11639-11643.
Jungwoo Lee, Meghan J. Cuddihy, George Cater, Nicholas A. Kotov “Engineering Liver Tissue Spheroids Using Inverted Colloidal Crystal Scaffolds” Biomaterials (2009) 30(27) 4687-4694.
Jungwoo Lee, Daniel G. Lilly, Christoper R. Doty, Paul Podsiadlo, Nicholas A. Kotov “In vitro Toxicity Testing of Nanoparticles in Three Dimensional Cell Culture” Small (2009) 5(10) 1213-1221. (Research Highlights in Nature Nanotechnology)
Jungwoo Lee, Nicholas A. Kotov “Notch Ligand Presenting Acellular 3D Microenvironments for Ex Vivo Human Hematopoietic Stem Cell Culture Made by Layer-by-Layer Assembly” Small (2009) 5(9) 1008-1013. (Front Cover Article)

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